| 產(chǎn)品編號(hào) | bs-9659R |
| 英文名稱 | FAM76B Rabbit pAb |
| 中文名稱 | FAM76B蛋白抗體 |
| 別 名 | Family with sequence similarity 76 member B; Hypothetical protein LOC143684; MGC33371; FA76B_HUMAN. |
| 研究領(lǐng)域 | 心血管 細(xì)胞生物 發(fā)育生物學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse (predicted: Human,Rat,Pig,Cow,Chicken,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 39 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FAM76B: 251-339/339 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
With approximately 135 million base pairs and 1,400 genes, chromosome 11 makes up around 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. The blood disorders Sickle cell anemia and β thalassemia are caused by HBB gene mutations. Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11. The FAM76B gene product has been provisionally designated FAM76B pending further characterization. Subcellular Location: Nucleus speckle. Post-translational modifications: Isoform 2 is ubiquitinated at Lys-225. Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the FAM76 family. SWISS: Q5HYJ3 Gene ID: 143684 Database links: Entrez Gene: 143684 Human Entrez Gene: 72826 Mouse SwissProt: Q5HYJ3 Human SwissProt: Q80XP8 Mouse |
| 產(chǎn)品圖片 |
Sample: Bone (Mouse) Lysate at 40 ug
Primary: Anti-FAM76B (bs-9659R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 39 kD
Observed band size: 39 kD
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