| 產(chǎn)品編號 | bs-0886R |
| 英文名稱 | MeV F Rabbit pAb |
| 中文名稱 | 麻疹病毒融合蛋白F抗體 |
| 別 名 | MeV; F; Measles virus Fusion glycoprotein F0; Fusion glycoprotein F2; Fusion glycoprotein F1; Fusion glycoprotein; FUS_MEASE. |
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Specific References (1) | bs-0886R has been referenced in 1 publications.
[IF=3.616] Katelyn D. Miller. et al. Murine BST2/tetherin promotes measles virus infection of neurons. Virology. 2021 Nov;563:38 IF ; Mouse.
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| 研究領(lǐng)域 | 細菌及病毒 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Measles virus) |
| 產(chǎn)品應(yīng)用 | ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 57 kDa |
| 檢測分子量 | |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from Measles virus fusion protein: 451-550/550 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
No data available. Function: Class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and plasma cell membrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes. Directs fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. This fusion is pH independent and occurs directly at the outer cell membrane. The trimer of F1-F2 (F protein) probably interacts with H at the virion surface. Upon HN binding to its cellular receptor, the hydrophobic fusion peptide is unmasked and interacts with the cellular membrane, inducing the fusion between cell and virion membranes. Later in infection, F proteins expressed at the plasma membrane of infected cells could mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis (By similarity). Subunit: Homotrimer of disulfide-linked F1-F2 (By similarity). Tissue Specificity: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass membrane protein. Post-translational modifications: The inactive precursor F0 is glycosylated and proteolytically cleaved into F1 and F2 to be functionally active. The cleavage is mediated by cellular proteases during the transport and maturation of the polypeptide (By similarity). Similarity: Belongs to the paramyxoviruses fusion glycoprotein family. Database links: SwissProt: P69353 Measles virus Entrez Gene: 1489800 Measles virus |
